Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

5.2K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
5.2K
Spermatogenesis01:41

Spermatogenesis

91.0K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
91.0K
Spermatogenesis01:22

Spermatogenesis

8.3K
Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
8.3K
Testes: Histology01:27

Testes: Histology

3.8K
A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
3.8K
Testes: Gross Anatomy01:19

Testes: Gross Anatomy

9.7K
The testes, also known as testicles, are the male gonads. They are housed within the scrotum, a sac-like structure located beneath the penis. The scrotum's primary role is to regulate the temperature of the testes, which is crucial for sperm production.
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
9.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification and validation of liquid biopsy-based methylation biomarkers for germ cell tumor subtypes.

Communications medicine·2026
Same author

International Society of Urological Pathology (ISUP) Consensus Conference on Precursor Lesions: Working Group 4 Precursor Lesions of Testis Results of a Premeeting Survey.

The American journal of surgical pathology·2026
Same author

Impact of Circulating Tumor DNA and Copy-Number Alterations on Clinical Outcome in Relapsed/Refractory Germ Cell Tumors Treated With Salvage High-Dose Chemotherapy.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

Safety of laparoscopic oophorectomy in a Dutch national pediatric cancer cohort.

F&S reports·2026
Same author

Low-amplitude copy number gains shape cancer through known and novel oncogenes with associated therapeutic vulnerabilities.

Nucleic acids research·2025
Same author

Clinical syndromes linked to biallelic germline variants in MCM8 and MCM9.

HGG advances·2025

Related Experiment Video

Updated: May 1, 2026

Germ Cell Transplantation and Testis Tissue Xenografting in Mice
10:41

Germ Cell Transplantation and Testis Tissue Xenografting in Mice

Published on: February 6, 2012

29.5K

Testicular germ cell tumors.

Leendert H J Looijenga

    Pediatric Endocrinology Reviews : PER
    |April 2, 2014
    PubMed
    Summary

    Human germ cell tumors are classified into three main types based on age. Understanding early pathogenetic steps in Type II tumors can help identify at-risk individuals and guide research.

    Area of Science:

    • Oncology
    • Developmental Biology
    • Pathobiology

    Background:

    • Human germ cell tumors exhibit diverse epidemiology, clinical behavior, and pathobiology.
    • Histological classification shows similarities to embryogenesis, leading to five recognized types.
    • Three types are relevant to male germ cells: Type I (neonates/infants), Type II (adolescents/adults), and Type III (elderly).

    Purpose of the Study:

    • To elucidate the earliest pathogenetic steps in human germ cell tumors, particularly Type II (seminomas and nonseminomas).
    • To understand how disturbed gonadal physiology impacts embryonic germ cell maturation.
    • To identify precursors like carcinoma in situ and gonadoblastoma.

    Main Methods:

    • Review of recent studies on germ cell tumor pathogenesis.

    More Related Videos

    Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency
    14:45

    Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

    Published on: August 6, 2014

    18.8K
    Teratoma Generation in the Testis Capsule
    05:24

    Teratoma Generation in the Testis Capsule

    Published on: November 7, 2011

    23.9K

    Related Experiment Videos

    Last Updated: May 1, 2026

    Germ Cell Transplantation and Testis Tissue Xenografting in Mice
    10:41

    Germ Cell Transplantation and Testis Tissue Xenografting in Mice

    Published on: February 6, 2012

    29.5K
    Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency
    14:45

    Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

    Published on: August 6, 2014

    18.8K
    Teratoma Generation in the Testis Capsule
    05:24

    Teratoma Generation in the Testis Capsule

    Published on: November 7, 2011

    23.9K
  • Analysis of the role of germ cells and micro-environment in maturation.
  • Correlation of gonadal "testicularization" with precursor histology.

    • Main Results:

    • Significant advances in understanding the earliest pathogenetic steps of Type II germ cell tumors.
    • Identification of maturation arrest of embryonic germ cells as a key event.
    • Carcinoma in situ and gonadoblastoma identified as precursors to seminomas and nonseminomas.

    Conclusions:

    • Disturbed gonadal physiology can block germ cell maturation, leading to precursor lesions.
    • The degree of gonadal "testicularization" influences precursor histology.
    • These insights aid in defining individuals at risk for germ cell malignancy and refining research approaches.