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Visualization of nucleic acid sequence structural information.

K Stüber1

  • 1Max-Planck-Institut für Züchtungsforschung, Köln, FRG.

Computer Applications in the Biosciences : CABIOS
|January 1, 1985
PubMed
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This study introduces interactive Pascal programs for analyzing nucleic acid sequences. These tools visualize structural information, including homology, repeats, and secondary structures, using line printers for accessibility.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Molecular Biology

Background:

  • Accurate analysis of nucleic acid sequences is crucial for understanding biological functions.
  • Existing tools may lack interactive features or require specialized hardware for visualization.
  • Efficient display of structural information aids in biological interpretation.

Purpose of the Study:

  • To develop and present interactive Pascal programs for analyzing and displaying nucleic acid sequence structures.
  • To provide accessible visualization methods for homology, repeats, and secondary structures.
  • To integrate these tools into a comprehensive nucleic acid sequence analysis package.

Main Methods:

  • Development of interactive Pascal programs utilizing specific layout procedures.

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  • Implementation of algorithms for predicting and displaying secondary structures of RNA/DNA molecules.
  • Adaptation of output for standard line printers, eliminating the need for special plotting devices.
  • Compatibility with various DNA database systems for sequence input.

    • Main Results:

    • Successful creation of interactive programs for nucleic acid sequence analysis.
    • Effective visualization of homology and repeat matrices.
    • Accurate prediction and overlap-free display of RNA/DNA secondary structures.
    • Capability to predict and display internal repeats within sequences.
    • Generation of output compatible with line printers, enhancing accessibility.

    Conclusions:

    • The developed Pascal programs offer an accessible and efficient method for analyzing and visualizing nucleic acid sequence structures.
    • These tools can be readily used with standard line printers and various DNA database inputs.
    • The programs represent a valuable addition to the general toolkit for nucleic acid sequence analysis.