Related Experiment Video
Updated: May 1, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
Published on: May 30, 2025
Hormone abnormalities are not related to the erectile dysfunction and decreased libido found in many men with
Raj Satkunasivam1, Michael Ordon2, Brian Hu3
1Division of Urology, Department of Surgery, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada; Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Objective:
To evaluate whether hormonal markers predict erectile dysfunction (ED) and symptoms of T deficiency syndrome (TDS), which are commonly found in the population of infertile men.
Design:
Retrospective study utilizing a prospectively maintained infertility database.
Setting:
A tertiary referral center.
Patient(S):
A total of 1,750 of 2,783 men presenting for evaluation of infertility between 1995 and 2010 completed validated questionnaires.
Intervention(S):
Androgen Deficiency in the Aging Male (ADAM) and Sexual Health Inventory for Men questionnaires were administered. Baseline risk factors for ED and TDS were also measured. Subjects underwent serum hormone evaluation for total T, calculated bioavailable T, sex hormone-binding globulin, E2, LH, FSH, and PRL.
Main Outcome Measure(S):
Multivariable logistic regression modeling was used to determine the significance of hormonal markers in predicting ED (Sexual Health Inventory for Men score <22) and/or a positive ADAM score.
Result(S):
The prevalence of ED and a positive response to the ADAM questionnaire were 30.5% and 45.2%, respectively, in this population (mean age, 36 years). Low serum T (total T < 10 nmol/L) was found in 29.4%. Neither T nor bioavailable T was significantly associated with the symptoms of ED or TDS on multivariable regression analysis.
Conclusion(S):
Erectile dysfunction and TDS in young, infertile men seem to be unrelated to hormone changes.
Related Concept Videos
Infertility in Males
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Menopause
Spermatogenesis
Testosterone: Functions and Regulation
Infertility in Females
Endometriosis, a condition characterized by abnormal growth of...

