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Long noncoding RNAs, emerging players in muscle differentiation and disease
Maria Victoria Neguembor, Mathivanan Jothi, Davide Gabellini1
1Dulbecco Telethon Institute at San Raffaele Scientific Institute, Division of Regenerative Medicine, Stem cells, and Gene therapy, DIBIT2, 5A3, Via Olgettina 58, 20132 Milano, Italy. gabellini.davide@hsr.it.
Skeletal Muscle
|April 2, 2014
Summary
Long noncoding RNAs (lncRNAs) are abundant and versatile regulators of gene expression. This review explores their roles in muscle development, differentiation, and diseases like muscular dystrophies.
Area of Science:
- Molecular Biology
- Genomics
- Developmental Biology
Background:
- The mammalian genome produces numerous noncoding RNAs, with long noncoding RNAs (lncRNAs) being the most abundant and functionally diverse.
- lncRNAs are critical regulators of gene expression, influencing development, cell identity, and disease processes.
Purpose of the Study:
- To review recent advancements in understanding lncRNA biology concerning muscle development and differentiation.
- To discuss the involvement of lncRNAs in muscle diseases, specifically Duchenne and facioscapulohumeral muscular dystrophies.
Main Methods:
- Literature review of recent research on lncRNAs in muscle biology.
- Analysis of studies focusing on lncRNA function in muscle development and disease.
Main Results:
- lncRNAs play significant roles in regulating gene expression during muscle development and differentiation.
- Dysregulation of lncRNAs is implicated in the pathogenesis of various muscle disorders.
Conclusions:
- lncRNAs are key players in muscle biology, impacting both normal development and disease states.
- Further research into lncRNAs offers potential therapeutic avenues for muscle-related diseases.
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