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Updated: May 1, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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Proteome changes in platelets after pathogen inactivation--an interlaboratory consensus.

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This summary is machine-generated.

Pathogen inactivation (PI) of platelet concentrates (PCs) shows promise in reducing microbial contamination but may affect platelet function and accelerate storage lesions. Different PI systems impact platelet proteins uniquely, influencing their biological functions.

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Area of Science:

  • Blood banking and transfusion medicine
  • Proteomics and platelet biology
  • Infectious disease control in transfusion

Background:

  • Pathogen inactivation (PI) of platelet concentrates (PCs) is crucial for transfusion safety, reducing microbial risks and residual leukocytes.
  • Clinical trials demonstrate the efficacy and safety of PI-PCs, but concerns remain regarding hemostatic activity and platelet function.
  • Proteomic studies are essential to understand molecular-level damages caused by PI treatments in PCs.

Purpose of the Study:

  • To review and synthesize findings from proteomic analyses of PCs treated with Mirasol, Intercept, and Theraflex UV-C systems.
  • To discuss the impact of PI-mediated protein damage on platelet biological functions.
  • To provide a basis for understanding PI effects on platelet function and for future PI technology development.

Main Methods:

  • Comprehensive review of proteomic studies on Mirasol, Intercept, and Theraflex UV-C treated PCs.
  • Analysis of reported protein alterations and their functional implications.
  • Comparison of PI-specific impacts on platelet proteomes.

Main Results:

  • PI has a relatively minor impact on the overall platelet proteome.
  • PI treatments can accelerate platelet storage lesions, aligning with current models.
  • Different PI systems exhibit distinct effects: Mirasol affects adhesion/shape change, Intercept impacts intracellular activation pathways, and Theraflex influences shape change/aggregation.

Conclusions:

  • PI treatments differentially affect platelet proteomes and functions.
  • Understanding PI-mediated protein damage is key to optimizing PI technologies for PCs.
  • Further research on PI and storage duration is needed, as PI may allow extended PC shelf life by mitigating bacterial risks.