Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multimodal Investigation of Angiogenesis and Its Prevention by Small Compounds in a Zebrafish Cancer Model.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation.

Cancer cell·2024
Same author

A multistep computational approach reveals a neuro-mesenchymal cell population in the embryonic hematopoietic stem cell niche.

Development (Cambridge, England)·2024
Same author

Comparative transcriptomics coupled to developmental grading via transgenic zebrafish reporter strains identifies conserved features in neutrophil maturation.

Nature communications·2024
Same author

Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy.

Cell stem cell·2023
Same author

Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence.

eLife·2023

Related Experiment Video

Updated: May 1, 2026

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish
07:00

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish

Published on: October 8, 2018

10.3K

Perspectives on antigen presenting cells in zebrafish.

Kanako L Lewis1, Natasha Del Cid1, David Traver1

  • 1Division of Biological Sciences, University of California, San Diego, La Jolla, CA, United States.

Developmental and Comparative Immunology
|April 2, 2014
PubMed
Summary

Zebrafish antigen-presenting cells (APCs), including macrophages, dendritic cells (DCs), and B cells, are reviewed for their role in initiating adaptive immunity. Their functions are compared to mammalian APCs, offering insights into vertebrate immune evolution.

Keywords:
Antigen-presenting cellsB lymphocytesDendritic cellsMacrophagesZebrafish

More Related Videos

Author Spotlight: Mapping Cellular Connectivity in the Zebrafish Nervous System During Development and Regeneration
06:08

Author Spotlight: Mapping Cellular Connectivity in the Zebrafish Nervous System During Development and Regeneration

Published on: July 5, 2024

1.6K
Non-invasive Imaging of Disseminated Candidiasis in Zebrafish Larvae
10:45

Non-invasive Imaging of Disseminated Candidiasis in Zebrafish Larvae

Published on: July 30, 2012

14.2K

Related Experiment Videos

Last Updated: May 1, 2026

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish
07:00

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish

Published on: October 8, 2018

10.3K
Author Spotlight: Mapping Cellular Connectivity in the Zebrafish Nervous System During Development and Regeneration
06:08

Author Spotlight: Mapping Cellular Connectivity in the Zebrafish Nervous System During Development and Regeneration

Published on: July 5, 2024

1.6K
Non-invasive Imaging of Disseminated Candidiasis in Zebrafish Larvae
10:45

Non-invasive Imaging of Disseminated Candidiasis in Zebrafish Larvae

Published on: July 30, 2012

14.2K

Area of Science:

  • Immunology
  • Comparative Biology
  • Evolutionary Medicine

Background:

  • Antigen presentation is crucial for activating T lymphocytes.
  • Mammalian antigen-presenting cells (APCs) include dendritic cells (DCs), macrophages, and B cells.
  • The precise role of zebrafish APCs in initiating adaptive immunity requires further clarification.

Purpose of the Study:

  • To review the characterization of zebrafish macrophages, DCs, and B cells.
  • To evaluate evidence supporting their function as true APCs.
  • To discuss the conservation of APC activity across vertebrates and the utility of zebrafish in studying immune evolution.

Main Methods:

  • Literature review of zebrafish immunology research.
  • Analysis of studies characterizing zebrafish APC populations.
  • Comparative analysis of zebrafish and mammalian APC functions.

Main Results:

  • Zebrafish possess macrophages, DCs, and B cells with potential APC capabilities.
  • Evidence suggests these cells initiate adaptive immune responses in zebrafish.
  • Conservation of APC function across vertebrate species is indicated.

Conclusions:

  • Zebrafish APCs play a significant role in initiating adaptive immunity.
  • Zebrafish serve as a valuable model for understanding the evolution of antigen presentation.
  • Further research in zebrafish can illuminate fundamental aspects of vertebrate adaptive immunity.