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Alpha fetoprotein inhibits aggregation of human platelets
1Department of General and Experimental Pathology, Medical Academy, Białystok, Poland.
Haematologia
|January 1, 1989
Abstract:
The effect of human alpha-fetoprotein (AFP) on platelet aggregation induced by physiological (ADP, PAF, collagen, arachidonic acid) and aphysiological (ionophore A 23,187) activators was investigated. It was found that AFP at the concentrations of 60-750 micrograms/ml, i.e. far below that observed in human blood, inhibits platelet aggregation induced by physiological activators. Platelet aggregation induced by arachidonic acid was two-four times more sensitive to inhibition by AFP than that induced by other physiological agonists, whereas aggregation induced by A 23,187 was not affected by AFP even at concentration of 750 micrograms/ml.