THADA gene polymorphism and prostate cancer risk: a meta-analysis

Area of Science:

• Genetics
• Oncology
• Epidemiology

Background:

• The single nucleotide polymorphism (SNP) rs1465618 in the THADA gene has been associated with prostate cancer (PCa) risk in European populations.
• The role of this SNP in PCa risk across diverse ethnic groups remains unclear.

Purpose of the Study:

• To investigate the association between the THADA gene SNP rs1465618 and PCa risk in a Chinese population.
• To conduct a meta-analysis evaluating the SNP's relevance to PCa risk across multiple populations.

Main Methods:

• Genotyping of the rs1465618 SNP using high-resolution melting (HRM) analysis in a Chinese case-control study (289 PCa patients, 288 controls).
• Meta-analysis including 36,313 PCa patients and 36,485 controls to assess the association of rs1465618 with PCa risk globally.

Main Results:

• The rs1465618 SNP was significantly associated with PCa risk in the Chinese population (p = 0.026, OR = 1.327).
• The rs1465618 variant genotype correlated with increased PCa aggressiveness in the Chinese cohort (p = 0.044, OR = 2.053).
• Meta-analysis confirmed a significant association between rs1465618 and PCa risk across multiple populations (p = 1.0×10(-8), OR = 1.127).

Conclusions:

• The rs1465618 SNP in the THADA gene may represent a shared susceptibility factor for prostate cancer in various populations.
• Polymorphisms within the THADA gene could influence both PCa susceptibility and disease progression.