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Related Experiment Videos

Immunoreactive cytokeratins in plasmacytomas.

A C Wotherspoon1, A J Norton, P G Isaacson

  • 1Department of Histopathology, University College, London, UK.

Histopathology
|February 1, 1989
PubMed
Summary

Plasma cell tumors, including multiple myeloma, can express cytokeratin, a protein usually found in epithelial cells. This finding is more common than expected and can lead to misdiagnosis in diagnostic pathology.

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Area of Science:

  • Pathology
  • Oncology
  • Immunohistochemistry

Background:

  • Plasma cell tumors, such as multiple myeloma and solitary plasmacytoma, are neoplastic proliferations of plasma cells.
  • Immunohistochemistry is a crucial diagnostic tool in identifying cell lineage and differentiating tumors.

Purpose of the Study:

  • To investigate the expression of cytokeratin in plasma cell tumors.
  • To assess the diagnostic implications of cytokeratin reactivity in these neoplasms.

Main Methods:

  • Analysis of fourteen plasma cell tumors (solitary plasmacytoma and multiple myeloma) using immunohistochemistry.
  • Utilized a panel of antibodies, including those for immunoglobulin light chains, cytokeratins, and leucocyte common antigen, on formalin-fixed, paraffin-embedded tissues.

Main Results:

  • All fourteen cases exhibited immunoglobulin light chain restriction, confirming their plasma cell origin.
  • Five out of fourteen tumors showed reactivity to anti-cytokeratin antibodies.
  • Of the cytokeratin-positive cases, four were negative for leucocyte common antigen, and one was weakly positive.

Conclusions:

  • Cytokeratin expression is a more frequent finding in plasma cell tumors than previously recognized.
  • The presence of anti-cytokeratin reactivity in plasma cell tumors poses a significant diagnostic challenge and potential pitfall in histopathological evaluation.

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