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Cytokeratin expression in cervical epithelium: an immunohistological study of normal, wart virus-infected and
J R Whittaker1, A M Samy, J P Sunter
1Department of Gyaecological Oncology, Queen Elizabeth Hospital, Gateshead, UK.
Histopathology
|February 1, 1989
Abstract:
In this study using a panel of anticytokeratin antibodies and an indirect immunoperoxidase method, we examined cervical squamous epithelia including mature stratified epithelium, immature squamous metaplasia, CIN 1, 2 and 3, wart virus infection and squamous carcinoma. Changes from the normal patterns of staining were inconsistently seen in CIN 1 and 2, but in CIN 3 the changes were more marked, and consisted of a loss of stratification of the staining pattern and a patchy reduction in staining. Invasive carcinomas showed a similar staining pattern to CIN 3 lesions.