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Mean platelet volume is related with ischemic stroke in patients with sinus rhythm

Buğra Özkan1, Osman Z Arik, Mehmet Y Gözükara

  • 1aDepartment of Cardiology, Bucak State Hospital, Burdur bDepartment of Cardiology, Gümüşhane State Hospital, Gümüşhane cDepartment of Internal Medicine, Mersin State Hospital, Mersin dDepartment of Cardiology, Adana Numune Training and Research Hospital, Adana eDepartment of Cardiology, Gazi University Faculty of Medicine, Ankara fDepartment of Cardiology, Kayseri Training and Research Hospital, Kayseri and gDepartment of Neurology, Bucak State Hospital, Burdur Turkey.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|April 2, 2014
PubMed

Insights

Higher mean platelet volume (MPV) is linked to ischemic stroke in patients with sinus rhythm. This finding suggests MPV may be an independent predictor of stroke risk in this population.

Area of Science:

  • Neurology
  • Hematology
  • Cardiology

Background:

  • Stroke is a leading global cause of disability.
  • Atrial fibrillation and left atrial enlargement are known risk factors for ischemic stroke.
  • Mean platelet volume (MPV) is elevated in patients with ischemic stroke and atrial fibrillation.

Purpose of the Study:

  • To investigate the association between higher MPV and ischemic stroke in patients with sinus rhythm.
  • To determine if MPV is an independent predictor of ischemic stroke in this specific patient group.

Main Methods:

  • A study evaluated 74 patients with ischemic stroke in sinus rhythm and 90 healthy controls.
  • Methods included physical and echocardiographic examinations, 24-48h Holter monitoring, and complete blood counts.
  • Statistical analysis compared demographic data, comorbidities, left atrial diameter, and MPV between groups.

Main Results:

  • No significant differences in age, sex, or comorbidities were found between groups.
  • Left atrial diameter was higher in the stroke group but within normal limits.
  • Mean platelet volume (MPV) was significantly higher in patients with ischemic stroke and identified as an independent determinant.

Conclusions:

  • Elevated MPV is associated with acute ischemic stroke in patients with sinus rhythm, even without heart failure or left atrial enlargement.
  • Both MPV and left atrial diameter are independent predictors of ischemic stroke in this population.
  • MPV may serve as a valuable biomarker for assessing ischemic stroke risk.

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