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Related Concept Videos

Histone Modification02:32

Histone Modification

14.6K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Histone Modification02:32

Histone Modification

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Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Duplication of Chromatin Structure02:05

Duplication of Chromatin Structure

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The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
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Spreading of Chromatin Modifications02:25

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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
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Chromosome Replication02:31

Chromosome Replication

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Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins.  This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin...
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Related Experiment Video

Updated: May 1, 2026

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
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Histone lysine methylation and chromatin replication.

Carlos Rivera1, Zachary A Gurard-Levin2, Geneviève Almouzni2

  • 1Fundación Ciencia & Vida, Santiago, Chile.

Biochimica Et Biophysica Acta
|April 2, 2014
PubMed
Summary

Histone lysine methylation plays a key role in DNA replication and chromatin assembly. This mark influences replication initiation and the inheritance of chromatin structure during cell division.

Keywords:
Chromatin assemblyEpigeneticsGenomic integrityHeterochromatinHistonesPost-translational modifications

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Area of Science:

  • Molecular Biology
  • Epigenetics
  • Genomics

Background:

  • DNA replication and chromatin organization are essential for maintaining genome integrity in eukaryotes.
  • Histone variants and post-translational modifications, including lysine methylation, influence DNA metabolic processes.
  • Understanding the role of lysine methylation in chromatin replication is crucial for comprehending genome stability.

Purpose of the Study:

  • To review the role of histone lysine methylation in chromatin replication.
  • To explore how lysine methylation regulates early replication steps.
  • To discuss the impact of lysine methylation inheritance on chromatin reassembly and maintenance.

Main Methods:

  • Literature review of studies on histone lysine methylation and DNA replication.
  • Analysis of mechanisms regulating chromatin assembly post-replication.
  • Examination of heterochromatin as a model for lysine methylation inheritance.

Main Results:

  • Lysine methylation is implicated in regulating the early stages of DNA replication.
  • Chromatin reassembly involves newly synthesized and parental histones, affecting lysine methylation mark inheritance.
  • Inherited lysine methylation patterns are critical for maintaining chromatin landscapes, particularly heterochromatin.

Conclusions:

  • Histone lysine methylation is a significant epigenetic mark influencing DNA replication and chromatin inheritance.
  • The inheritance of lysine methylation marks contributes to the maintenance of chromatin structure and genome integrity.
  • Further research into the mechanisms of lysine methylation inheritance can elucidate epigenetic regulation.