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Axon Stretch Growth: The Mechanotransduction of Neuronal Growth
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Oscillations in a neurite growth model with extracellular feedback
V I Mironov1, A S Romanov1, A Yu Simonov1
1Nizhny Novgorod Neuroscience Centre, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
Neuroscience Letters
|April 2, 2014
Summary
Extracellular signals can cause neurite oscillations, trapping them in a field. This study models how these signals influence neurite growth, revealing distinct developmental scenarios.
Area of Science:
- Neuroscience
- Cell Biology
- Biophysics
Background:
- Neurite elongation is crucial for neural development and function.
- Extracellular signaling molecules play a significant role in regulating cell growth and differentiation.
- Tubulin dynamics are fundamental to the structural integrity and extension of neurites.
Purpose of the Study:
- To investigate the impact of extracellular signaling on neurite elongation dynamics.
- To model neurite growth influenced by feedback mechanisms involving tubulin production.
- To analyze the different developmental outcomes of neurites in response to extracellular fields.
Main Methods:
- Development of a mathematical model for neurite growth.
- Incorporation of extracellular signaling influence on tubulin production dynamics.
- Analysis of model predictions under varying distributions of signaling molecules.
Main Results:
- Extracellular feedback can induce oscillatory neurite elongation (growth and retraction).
- Oscillations can lead to neurites becoming trapped in non-uniform extracellular fields.
- Three distinct neurite development scenarios were predicted: monotonic, oscillatory, and growth-depressed.
Conclusions:
- Extracellular signaling feedback is a critical factor in determining neurite outgrowth patterns.
- Neurite oscillations can act as a mechanism to limit or halt neurite extension.
- The model provides insights into diverse neurite development trajectories within complex extracellular environments.
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