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Inflammatory response of macrophages in infection

Ling Zhang1, Cheng-Cai Wang

  • 1Department of Anesthesiology, Changzhen Hospital, Second Military Medical University, Shanghai 200003, China. wangchengcai81@sina.com.

Hepatobiliary & Pancreatic Diseases International : HBPD INT
|April 2, 2014
PubMed
Abstract

Insights

Macrophages are key innate immune cells that clear pathogens. Their inflammatory response to infection involves recognition, recruitment, microbicidal activity, and repair, all under complex molecular regulation.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Macrophages are crucial innate immune cells involved in numerous physiological and pathological processes.
  • Their primary role is the phagocytosis and elimination of invading pathogens.

Purpose of the Study:

  • To systematically review the inflammatory response of macrophages during infection.
  • To explore the molecular mechanisms regulating macrophage activation.

Main Methods:

  • A systematic literature search of PubMed was conducted.
  • 122 articles on macrophage inflammatory responses in infection were reviewed.

Main Results:

  • Macrophage inflammatory responses to infection involve pathogen recognition, cell recruitment/proliferation, microbicidal activity, and transition to an anti-inflammatory phenotype for tissue repair.
  • Recent discoveries highlight complex molecular regulation, including signaling molecules, membrane proteins, microRNAs, and epigenetic factors.

Conclusions:

  • The inflammatory response of macrophages during infection is a complex, ordered process.
  • This response is intricately regulated at the molecular level.

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