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Further mulinane and azorellane diterpenoids isolated from Mulinum crassifolium and Azorella compacta
Jorge Bórquez1, Alejandro Ardiles2, Luis Alberto Loyola3
1Laboratorio de Productos Naturales, Departamento de Química, Universidad de Antofagasta, Av. Coloso S-N, Antofagasta 1240000, Chile. jorge.borquez@uantof.cl.
Abstract:
The new mulinane diterpenoids 1 and 2 were isolated from the EtOAc extract of Mulinum crassifolium, while the rearranged mulinane 5, which was isolated for the first time from a natural source, was isolated from Azorella compacta. Compounds 1-2 were prepared by semi-synthesis thorough acetylation of the diterpene 17-acetoxymulinic acid (3). A mechanism of reaction was proposed, while the structures of the new compounds were elucidated on the basis of comprehensive spectroscopic analysis and computational methods.
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