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[Bactericidal action of lomefloxacin a new pyridonecarboxylic acid derivative]
S Koikeda1, H Okabe, H Shibata
1Department of Microbiology, Faculty of Pharmaceutical Sciences, Kanazawa University.
The Japanese Journal of Antibiotics
|January 1, 1989
Abstract:
Lomefloxacin (NY-198) [(+/-)-1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo -3- quinolinecarboxylic acid hydrochloride] strongly inhibited the growths of not only Gram-negative Escherichia coli but Gram-positive Staphylococcus aureus. In vivo and in vitro experiments showed deoxyribonucleic acid (DNA) synthesis was specifically inhibited by this drug in E. coli.