Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Beta-blockade in acute myocardial infarction.

J M Cruickshank1

  • 1Wythenshawe Hospital, Manchester, England.

Journal of Cardiovascular Pharmacology
|January 1, 1988
PubMed
Summary

Early beta-blockade treatment for acute myocardial infarction (MI) significantly reduces chest pain, infarct size, and mortality. This intervention is safe, cost-effective, and improves outcomes for eligible patients within 12 hours of symptom onset.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transversely excited atmospheric CO(2) laser radar with heterodyne detection.

Applied optics·2010
Same author

Are we misunderstanding beta-blockers.

International journal of cardiology·2007
Same author

New guidelines on hypertension.

Lancet (London, England)·2006
Same author

The hydration structure of guanidinium and thiocyanate ions: implications for protein stability in aqueous solution.

Proceedings of the National Academy of Sciences of the United States of America·2003
Same author

Renoprotection with antihypertensive agents.

Lancet (London, England)·2002
Same author

Beta-adrenergic blocking drugs in the treatment of hypertension.

Blood pressure·2002

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Coronary heart disease is a leading cause of death.
  • Acute myocardial infarction (MI) requires interventions to reduce myocardial oxygen demand.

Purpose of the Study:

  • To evaluate the benefits of early beta-blockade in patients with acute MI.
  • To assess the impact of beta-blockade on mortality, infarct size, and arrhythmias.

Main Methods:

  • Intravenous followed by oral administration of beta-blockers within 12 hours of chest pain onset.
  • Focus on beta 1-selective blockade, noting potential diminished benefit with intrinsic sympathomimetic activity (ISA).

Main Results:

  • Significant reduction in chest pain and infarct size (approx. 30%).
  • Decreased incidence of life-threatening ventricular arrhythmias, cardiac arrest, and reinfarction.
  • About 15% reduction in vascular mortality at 1 week post-MI, sustained at 1 year.

Conclusions:

  • Early intravenous, followed by oral, beta 1-selective blockade is a safe and effective treatment for acute MI.
  • The intervention reduces mortality and improves patient outcomes, offering significant cost-effectiveness.
  • Approximately 50% of eligible MI patients can benefit from this treatment.

Related Experiment Videos