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Atherosclerosis and atheroma plaque rupture: imaging modalities in the visualization of vasa vasorum and

Zhonghua Sun1

  • 1Discipline of Medical Imaging, Department of Imaging and Applied Physics, Curtin University, P.O. Box U1987, Perth, WA 6845, Australia.

Thescientificworldjournal
|April 2, 2014
PubMed

Insights

Invasive angiography shows plaque degree but not composition. New imaging methods are needed to assess atherosclerotic plaque components and vasa vasorum, crucial for predicting cardiac events.

Area of Science:

  • Cardiovascular Imaging
  • Atherosclerosis Research
  • Medical Diagnostics

Background:

  • Invasive angiography is the gold standard for diagnosing cardiovascular pathologies, offering high resolution for lumen stenosis.
  • However, it provides insufficient morphological assessment of atherosclerotic plaque components.
  • This limits the prediction of plaque vulnerability and associated risks.

Purpose of the Study:

  • To review evidence-based imaging modalities for comprehensive atherosclerotic plaque characterization.
  • To evaluate their potential in assessing plaque composition, burden, and neovascularization.
  • To highlight the role of vasa vasorum in atherosclerosis progression and complications.

Main Methods:

  • Review of evidence-based literature on various imaging modalities.
  • Analysis of studies focusing on atherosclerotic plaque characterization.
  • Examination of the role of vasa vasorum in cardiovascular pathologies.

Main Results:

  • Current imaging methods inadequately assess atherosclerotic plaque composition and vulnerability.
  • Vasa vasorum are increasingly recognized for their critical role in plaque initiation, progression, and adverse cardiac events.
  • Emerging imaging techniques show promise for detailed plaque analysis.

Conclusions:

  • Comprehensive characterization of atherosclerotic plaque requires advanced imaging beyond conventional angiography.
  • Understanding plaque composition and vasa vasorum status is vital for predicting major adverse cardiac events.
  • Further research into novel imaging modalities is essential for improved cardiovascular risk assessment.

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