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Updated: May 1, 2026

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Refractory Postinflammatory Hyperpigmentation Treated Fractional CO2 Laser.

Yasemin Oram¹, A Deniz Akkaya¹

¹Department of Dermatology, V.K. Foundation American Hospital of Istanbul, Istanbul, Turkey.

The Journal of Clinical and Aesthetic Dermatology

|April 2, 2014

Summary

Fractional CO2 laser therapy effectively treated recalcitrant postinflammatory hyperpigmentation in a Fitzpatrick skin type III patient. Two sessions led to complete lesion clearance without complications, demonstrating its efficacy.

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Area of Science:

Dermatology
Laser Medicine

Background:

Postinflammatory hyperpigmentation (PIH) is a common skin condition resulting from inflammation.
Topical treatments are first-line, but recalcitrant PIH poses a clinical challenge.

Purpose of the Study:

To evaluate the efficacy of fractional CO2 laser in treating refractory postinflammatory hyperpigmentation.

Main Methods:

A case study of a 24-year-old woman with Fitzpatrick skin type III and recalcitrant PIH.
Treatment involved two sessions of fractional CO2 laser with a one-month interval.

Main Results:

Complete clearance of postinflammatory hyperpigmentation was observed after two treatment sessions.
No complications were reported following the fractional CO2 laser treatment.

Conclusions:

Fractional CO2 laser, when used with conservative settings and appropriate post-treatment care, can be highly effective for recalcitrant PIH.
While some lasers can induce PIH, fractional CO2 lasers offer a viable treatment option for specific cases.