Association study in three different populations between the GPR88 gene and major psychoses
Maria Del Zompo1, Jean-François Deleuze2, Caterina Chillotti3
1Section of Neurosciences and Clinical Psychopharmacology, Department of Biomedical Sciences, University of Cagliari Cagliari, Italy ; Unit of Clinical Pharmacology, Teaching Hospital of Cagliari, AOUCA Cagliari, Italy.
Molecular Genetics & Genomic Medicine
|April 2, 2014
Summary
Genetic association studies reveal G protein-coupled receptor 88 (GPR88) as a potential risk factor for bipolar disorder (BD) and schizophrenia (SZ). These findings highlight GPR88
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- G protein-coupled receptor 88 (GPR88) is highly expressed in the striatum and is a candidate gene for neuropsychiatric disorders.
- The GPR88 gene is located on chromosome 1p22-p21, a region previously associated with bipolar disorder (BD) in the Sardinian population.
Purpose of the Study:
- To investigate the association between GPR88 and the risk of developing bipolar disorder (BD) and schizophrenia (SZ).
- To evaluate GPR88 as a potential genetic risk factor for psychiatric diseases across diverse populations.
Main Methods:
- Genetic association analysis was conducted using a triad design (patient and both parents).
- Samples were recruited from Sardinian and Palestinian populations for BD, and Xhosa population in South Africa for SZ.
- Statistical analysis included correction for multiple testing.
Main Results:
- A significant positive association was found between GPR88 and BD in both Sardinian and Palestinian triads.
- A significant positive association was observed between GPR88 and SZ in the Xhosa population.
- After correction for multiple testing, the association between GPR88 and BD remained significant in the Palestinian population.
Conclusions:
- GPR88 is a potential candidate gene for bipolar disorder and schizophrenia.
- Further investigation of GPR88 in other populations is warranted to confirm its role in psychiatric diseases.
- These findings suggest GPR88's involvement in the genetic etiology of major psychiatric disorders.
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