Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcium antagonists in ischemic stroke.

C Fieschi1, C Argentino, D Toni

  • 1Department of Neurological Sciences, University of Rome La Sapienza, Italy.

Journal of Cardiovascular Pharmacology
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Common variable immunodeficiency disorders: Updated diagnostic criteria and genetics].

La Revue de medecine interne·2021
Same author

[Common variable immunodeficiency disorders: Part 2. Updated clinical manifestations and therapeutic management].

La Revue de medecine interne·2021
Same author

Efficacy of oral sirolimus as salvage therapy in refractory lichen planus associated with immune deficiency.

The British journal of dermatology·2018
Same author

[Not Available].

Italian journal of neurological sciences·2016
Same author

Infections Revealing Complement Deficiency in Adults: A French Nationwide Study Enrolling 41 Patients.

Medicine·2016
Same author

Evaluation of medical therapies of acute ischemic stroke.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same journal

SGLT2 Inhibitors and Progression of Chronic Kidney Disease in Patients with Elevated Lipoprotein(a): A Real-World Cohort Study.

Journal of cardiovascular pharmacology·2026
Same journal

Aspirin in primary prevention: a case for selective use.

Journal of cardiovascular pharmacology·2026
Same journal

GLP-1 Gene Therapy Trial for Obesity and Type 2 Diabetes: Towards a New Paradigm for Chronic Disease Treatment.

Journal of cardiovascular pharmacology·2026
Same journal

Expert Opinion: Restrictions, Precautions, or Normalcy? Defining Everyday Risk in Patients Treated With IL-1 Blockers for Recurrent Pericarditis.

Journal of cardiovascular pharmacology·2026
Same journal

The Therapeutic Role of Exercise in Diabetic Cardiomyopathy: Underlying Mechanisms and Interactions with Antidiabetic Medications.

Journal of cardiovascular pharmacology·2026
Same journal

Cardiovascular Adverse Events Associated with Immune Checkpoint Inhibitors from the Perspective of Gut Microecology: Potential Roles and Research Advances of the Gut Microbiota.

Journal of cardiovascular pharmacology·2026
See all related articles

This study on acute ischemic stroke found that severe deficits correlate with greater cerebral blood flow (CBF) impairment. Nimodipine treatment showed potential to increase CBF in the ischemic penumbra.

Area of Science:

  • Neurology
  • Radiology
  • Pharmacology

Background:

  • Acute ischemic stroke is a leading cause of disability.
  • Assessing cerebral blood flow (CBF) is crucial for understanding stroke pathophysiology.
  • The ischemic penumbra represents a target for therapeutic intervention.

Purpose of the Study:

  • To evaluate cerebral blood flow (CBF) changes in acute ischemic stroke patients.
  • To identify factors associated with CBF impairment and outcomes.
  • To investigate the effect of nimodipine on CBF in the ischemic penumbra.

Main Methods:

  • 39 patients with acute ischemic stroke underwent neurological examination, CT scan, cerebral angiography, and CBF-SPECT within 6 hours of symptom onset.
  • Seven patients received a second CBF-SPECT after intravenous nimodipine infusion.

Related Experiment Videos

  • Correlation analysis was performed between CBF, neurological deficit, CT findings, and outcomes.

    • Main Results:

    • Greater CBF impairment was associated with severe neurological deficit, poor outcome, cerebral arterial occlusion, and large CT hypodensity.
    • Nimodipine treatment led to a significant increase in CBF at the periphery of the ischemic zone.
    • These findings suggest nimodipine's potential efficacy in targeting the ischemic penumbra.

    Conclusions:

    • CBF impairment severity is linked to clinical and radiological indicators of stroke severity and prognosis.
    • Nimodipine demonstrates potential therapeutic effects on the ischemic penumbra in acute ischemic stroke.
    • CBF-SPECT is a valuable tool for assessing stroke severity and treatment response.