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Related Concept Videos

Diabetic Nephropathy01:28

Diabetic Nephropathy

32
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
32
Diabetic Retinopathy01:27

Diabetic Retinopathy

55
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
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Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

682
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
682
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

1.4K
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

679
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Related Experiment Video

Updated: May 1, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

798

Risk factor control is key in diabetic nephropathy.

Gareth Lewis, Alexander P Maxwell

    The Practitioner
    |April 3, 2014
    PubMed
    Summary

    Managing diabetes and hypertension is key to preventing diabetic nephropathy. Early detection through regular screening and timely intervention with RAAS inhibitors can significantly slow disease progression and reduce cardiovascular risks.

    Area of Science:

    • Nephrology
    • Endocrinology
    • Cardiology

    Background:

    • Diabetic nephropathy and cardiovascular disease share risk factors like prolonged diabetes, poor glycemic control, and hypertension.
    • Microalbuminuria is an early indicator of diabetic nephropathy risk.

    Purpose of the Study:

    • To highlight the importance of early detection and management of diabetic nephropathy.
    • To emphasize the role of blood pressure and glycemic control in preventing complications.

    Main Methods:

    • Annual urinary albumin-to-creatinine ratio (ACR) screening for type 2 diabetes patients from diagnosis, and for type 1 diabetes patients five years post-diagnosis.
    • Monitoring blood pressure, renal function, and urinary ACR annually in patients with diabetic nephropathy.

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    Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
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    Main Results:

    • Optimizing blood sugar and blood pressure control reduces the risk of diabetic nephropathy.
    • Lowering blood pressure to 130/80mmHg and proteinuria to <1 g/day slows disease progression and cardiovascular events.
    • Renin-angiotensin-aldosterone system (RAAS) inhibitors (ACEI or ARB) are crucial for managing hypertension and reducing cardiovascular risk in diabetic nephropathy.

    Conclusions:

    • Diabetic nephropathy requires consideration in diabetic patients with persistent albuminuria.
    • RAAS inhibitors should be prescribed to patients with diabetic nephropathy unless contraindicated, with careful management during illness or volume depletion.
    • Regular monitoring of blood pressure, renal function, and urinary ACR is essential for patients with diabetic nephropathy.