Resistance-based biosensor of Multi-Walled Carbon Nanotubes

Area of Science:

• Materials Science
• Biotechnology
• Sensor Technology

Background:

• Multi-Walled Carbon Nanotubes (MWNTs) offer significant resistance changes during immunoreactions, making them suitable for resistive biosensors.
• MWNTs are cost-effective and exhibit better biocompatibility compared to single-walled carbon nanotubes.
• Resistive measurement equipment is generally affordable and widely accessible.

Purpose of the Study:

• To develop a novel resistive biosensor utilizing Multi-Walled Carbon Nanotubes (MWNTs).
• To immobilize an antigen onto the MWNT surface via a silanization process.
• To evaluate the sensor's performance for potential disease diagnosis.

Main Methods:

• Fabrication of a resistive biosensor using Multi-Walled Carbon Nanotubes (MWNTs).
• Immobilization of an antigen onto the MWNT surface through a silanization technique.
• Monitoring changes in electrical conductivity upon interaction with antigen and antibody.

Main Results:

• The biosensor demonstrated an increase in conductivity upon the addition of the antigen.
• A decrease in conductivity was observed when the antibody was introduced to the sensor.
• These conductivity changes indicate the sensor's responsiveness to specific biomolecular interactions.

Conclusions:

• The developed MWNT-based resistive biosensor is a promising candidate for disease diagnosis.
• The sensor's ability to detect antigen and antibody through conductivity modulation highlights its diagnostic potential.
• Further research can explore its application in various diagnostic scenarios.