Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.3K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.3K
Vaccine Production01:23

Vaccine Production

144
Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
144
Vaccinations01:51

Vaccinations

44.1K
Overview
44.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A comparative analysis of the immunotranscriptomic features of DENV-1, -3, and -4 human challenge models.

The Journal of infectious diseases·2026
Same author

Core Content Related to Teaching Biomechanical Aspects of Human Movement for Physical Therapist Students: A Modified Delphi Study.

Journal, physical therapy education·2026
Same author

Dengue antibody dynamics resolved at epitope level using a dengue 1 human infection model.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2026
Same author

Longitudinal analysis of viral and host RNA in blood and saliva during controlled human dengue virus 3 infections.

Journal of virology·2026
Same author

Addressing the elephant in the room: Proceedings of the third annual Dengue Endgame Summit.

PLoS neglected tropical diseases·2026
Same author

Development and optimization of self-collected, field stable, saliva-based immunoassays for scalable epidemiological surveillance of pathogen-specific immunity.

medRxiv : the preprint server for health sciences·2026
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
See all related articles

Related Experiment Video

Updated: May 1, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

6.4K

Developing a dengue vaccine: progress and future challenges.

Stephen J Thomas1

  • 1Walter Reed Army Institute of Research, Silver Spring, Maryland.

Annals of the New York Academy of Sciences
|April 3, 2014
PubMed
Summary
This summary is machine-generated.

Developing effective dengue vaccines and antiviral drugs faces significant hurdles. Overcoming challenges in immunology, disease modeling, and assay platforms is crucial for future dengue control strategies.

Keywords:
antiviraldengueimmunologyvaccine

More Related Videos

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection
06:00

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection

Published on: January 26, 2024

2.3K
Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
08:36

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Published on: November 1, 2018

33.7K

Related Experiment Videos

Last Updated: May 1, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

6.4K
Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection
06:00

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection

Published on: January 26, 2024

2.3K
Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
08:36

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Published on: November 1, 2018

33.7K

Area of Science:

  • Public Health
  • Infectious Diseases
  • Vaccinology

Background:

  • Dengue fever is a growing global health threat, particularly in tropical and subtropical regions.
  • Millions seek treatment annually for dengue, yet safe and effective vaccines or antiviral drugs are still lacking.
  • Over 70 years of research have failed to yield a successful dengue vaccine or treatment.

Purpose of the Study:

  • To identify key obstacles hindering dengue vaccine and drug development.
  • To challenge existing assumptions about dengue vaccine correlates of protection.
  • To propose alternative development pathways for future dengue interventions.

Main Methods:

  • Review of existing research on dengue immunology, disease modeling, and assay platforms.
  • Analysis of recent clinical trial data for dengue vaccine candidates.
  • Evaluation of common vaccine development strategies in the context of dengue.

Main Results:

  • Significant knowledge gaps persist in dengue immunology and pathogenesis.
  • The lack of validated animal or human disease models impedes research.
  • Suboptimal immune response measurement platforms hinder vaccine efficacy assessment.
  • Recent vaccine trial results question established correlates of protection.

Conclusions:

  • Existing dengue research and development pathways are insufficient for creating effective vaccines or drugs.
  • Future dengue vaccine development requires exploring novel approaches beyond traditional methods.
  • Addressing fundamental research gaps is essential for advancing dengue control.