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Chromosome microarray analysis: a case report of infertile brothers with CATSPER gene deletion
Deepika Jaiswal1, Vertika Singh1, U S Dwivedi2
1Department of Molecular and Human Genetics, Banaras Hindu University, Varanasi, India.
Abstract:
We present the case of two brothers who were referred to a male infertility clinic for infertility workup. Conventional chromosome analysis and Y chromosome microdeletions did not reveal any genetic alterations. We utilized the chromosome microarray analysis (CMA) to identify novel and common variations associated with this severely impaired spermatogenesis cases. CMA specific results showed a common deletion in the 15q15.3 region that harbors genes like CATSPER2, STRC and PPIP5K1 in both cases (M18 and M19). In addition we identified small duplication in X and 11 chromosomes of M19. This is the first familial case report from India on occurrence of CATSPER gene deletion in human male infertility.
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