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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

1.4K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Kidney Transplant II: Surgical Procedure01:26

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Related Experiment Video

Updated: May 1, 2026

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
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Ketorolac after free tissue transfer: a comparative effectiveness study.

J Robert Schleiffarth, Rodrigo Bayon, Kristi E Chang

    The Annals of Otology, Rhinology, and Laryngology
    |April 3, 2014
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    Summary
    This summary is machine-generated.

    Ketorolac did not significantly reduce pain or opioid use after head and neck free tissue transfer. However, it was safely used as an anti-platelet agent without increasing bleeding complications.

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    Area of Science:

    • Surgical reconstruction
    • Head and neck surgery
    • Pharmacology

    Background:

    • Free tissue transfer is a complex procedure for head and neck defect reconstruction.
    • Postoperative pain management and bleeding risk are critical concerns.
    • Ketorolac, a nonsteroidal anti-inflammatory drug, has anti-platelet properties.

    Purpose of the Study:

    • To compare postoperative pain and complications in head and neck free tissue transfer patients receiving ketorolac versus those who did not.
    • To evaluate ketorolac's efficacy as an anti-platelet agent in this patient population.

    Main Methods:

    • Retrospective cohort study of 138 head and neck free tissue transfers.
    • Patients were divided into ketorolac and non-ketorolac groups.
    • Outcomes measured: postoperative analgesic use, pain scores, and bleeding complications.

    Main Results:

    • No significant difference in narcotic requirements between ketorolac and non-ketorolac groups.
    • Ketorolac group reported higher mean pain scores (3.1 vs 2.4, P = .004).
    • Ketorolac use was not associated with increased transfusion needs or drain duration.

    Conclusions:

    • Ketorolac did not provide significant analgesic benefits for pain or opioid consumption.
    • Ketorolac can be safely administered as an anti-platelet agent post-reconstruction.
    • Narcotic requirements remained unchanged with ketorolac use.