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Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

Nanoparticles generated by PEG-Chrysin conjugates for efficient anticancer drug delivery.

Hui Zheng¹, Sai Li², Yuji Pu³

¹National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China; School of Chemical Engineering, Sichuan University, Chengdu, China.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V

|April 3, 2014

Summary

Novel PEG-Chrysin nanoparticles effectively deliver anticancer drug doxorubicin. These drug delivery systems show enhanced cellular uptake and potent anticancer activity, offering a new strategy for cancer therapy.

Keywords:

Anticancer activity Doxorubicin Drug delivery Nanoparticles mPEG-Chrysin conjugate π–π Stacking interaction

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Published on: October 5, 2017

Area of Science:

Biotechnology
Materials Science
Nanomedicine

Background:

Nanoparticle-based drug delivery systems are crucial for enhancing anticancer drug safety and efficacy.
Chrysin, a natural flavonoid, has shown potential anticancer properties but requires effective delivery methods.

Purpose of the Study:

To develop novel, self-assembled nanoparticles using PEG-Chrysin conjugates for doxorubicin delivery.
To investigate the physicochemical properties, drug release kinetics, cellular uptake, and in vitro anticancer efficacy of these nanoparticles.

Main Methods:

Fabrication of mPEG-Chrysin conjugates and their self-assembly into nanoparticles.
Loading of doxorubicin (DOX) into the nanoparticles.
Characterization of nanoparticle size, drug-drug interactions, drug release profiles, cellular uptake, and in vitro cytotoxicity.

Main Results:

DOX-loaded nanoparticles were successfully fabricated with mean diameters below 200 nm.
Evidence of strong π-π stacking interactions between the nanoparticle components and doxorubicin.
Drug release rate was dependent on PEG chain length, with shorter chains promoting faster release.
mPEG-Chrysin conjugates demonstrated no toxicity to fibroblasts and cancer cells.
mPEG1000-Chrysin nanoparticles exhibited superior cellular uptake and significantly lower IC50 values compared to mPEG2000-Chrysin nanoparticles.

Conclusions:

PEG-Chrysin nanoparticles represent a promising platform for targeted doxorubicin delivery.
The developed nanoparticles show enhanced anticancer efficacy and cellular internalization.
This approach offers a novel strategy for the development of advanced antitumor drug delivery systems.