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Relationship between mean platelet volume elevation and left ventricular mass index in hypertensive patients

Mustafa Ferzeyn Yavuzkir1, Ertuğrul Kurtoğlu2, Mücahid Yilmaz2

  • 1Department of Cardiology, School of Medicine, Firat University, Elazig, Turkey ferzeyn@hotmail.com.

The Journal of International Medical Research
|April 3, 2014
PubMed

Insights

Patients with untreated hypertension exhibit higher mean platelet volume (MPV), a marker of platelet activation. However, this elevated MPV did not correlate with left ventricular mass index (LVMI) in hypertensive individuals.

Area of Science:

  • Cardiology
  • Hematology
  • Hypertension Research

Background:

  • Mean platelet volume (MPV) serves as a general indicator of platelet activation.
  • Hypertension is associated with cardiovascular changes, including left ventricular hypertrophy.
  • The relationship between platelet activation markers and cardiac remodeling in hypertension requires further investigation.

Purpose of the Study:

  • To compare MPV in patients with and without hypertension.
  • To investigate the association between MPV and left ventricular mass index (LVMI) in hypertensive patients.

Main Methods:

  • Cross-sectional, observational study design.
  • Inclusion of newly diagnosed, untreated stage I-II hypertensive patients and healthy controls.
  • Measurement of MPV via automated hematology analyzer and LVMI via echocardiography.

Main Results:

  • Significantly higher MPV observed in the hypertensive group (10.3 ± 1.4 fl) compared to controls (9.2 ± 1.8 fl).
  • Significantly higher LVMI observed in the hypertensive group (115.9 ± 23.0 g/m²) compared to controls (95.7 ± 23.4 g/m²).
  • No significant correlation found between MPV and LVMI in the study population.

Conclusions:

  • Elevated MPV is present in patients with untreated hypertension.
  • Despite elevated MPV and LVMI in hypertensive patients, no direct correlation was established between these two parameters.
Abstract

Keywords:
Hypertensionleft ventricular mass indexmean platelet volume

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