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Non-invasive imaging for subclinical coronary atherosclerosis in patients with peripheral artery disease

Rasmus Sejersten Ripa1, Andreas Kjaer, Birger Hesse

  • 1Department of Clinical Physiology, Nuclear Medicine and PET, KF-4012 Rigshospitalet University Hospital, Blegdamsvej 9, DK-2100, Copenhagen, Denmark, ripa@sund.ku.dk.

Current Atherosclerosis Reports
|April 3, 2014
PubMed

Insights

Patients with peripheral artery disease (PAD) often have undetected coronary artery disease. Early detection using advanced imaging may improve risk assessment and personalize treatment for these high-risk individuals.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Diagnostic Imaging

Background:

  • Peripheral artery disease (PAD) is a significant risk factor for coronary artery disease (CAD).
  • A substantial proportion of PAD patients exhibit subclinical coronary atherosclerosis, even without symptoms.
  • Current screening strategies for coronary atherosclerosis in PAD lack consensus.

Purpose of the Study:

  • To review the association between PAD and CAD.
  • To discuss emerging non-invasive imaging techniques for characterizing coronary atherosclerotic plaques.
  • To highlight the potential for improved risk stratification and personalized therapy in PAD patients.

Main Methods:

  • Literature review of studies investigating coronary atherosclerosis in PAD patients.
  • Analysis of emerging in vivo non-invasive imaging modalities for plaque characterization.
  • Discussion of current gaps in screening protocols and future directions.

Main Results:

  • Prevalence of subclinical coronary artery disease in PAD patients varies widely but can exceed 50%.
  • No established consensus exists for screening PAD patients for coronary atherosclerosis.
  • Novel imaging methods offer enhanced in vivo characterization of atherosclerotic plaques.

Conclusions:

  • PAD patients represent a high-risk population for CAD.
  • Advanced non-invasive imaging may enable early detection of vulnerable plaques.
  • Improved risk stratification can lead to tailored therapeutic approaches for PAD patients.

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