Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.0K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K
Bone Remodeling01:40

Bone Remodeling

34.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.4K
Bone Structure01:55

Bone Structure

40.3K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
40.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptome analysis in osteoarthritis primary tissues identifies high-confidence effector genes.

Nature communications·2026
Same author

Artificial intelligence for detecting fetal orofacial clefts and advancing medical education.

Nature communications·2026
Same author

Multi-omic analysis of deep learning-derived phenotypes links ophthalmic imaging to cardiovascular and neurological traits.

Nature cardiovascular research·2026
Same author

From pixels to polygons: A survey of deep learning approaches for medical image-to-mesh reconstruction.

Medical image analysis·2026
Same author

National patient-reported outcome measures data and the National Joint Registry : a report on the data completeness and quality.

The bone & joint journal·2026
Same author

Fourier-Net+: Band-Limited Spatial Representation for Efficient Medical Image Registration.

IEEE transactions on neural networks and learning systems·2026

Related Experiment Video

Updated: May 1, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

7.4K

Statistical shape and appearance models in osteoporosis.

Isaac Castro-Mateos1, Jose M Pozo, Timothy F Cootes

  • 1Center for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), Mechanical Engineering Department, The University of Sheffield, Sheffield, UK, isaac.casm@sheff.ac.uk.

Current Osteoporosis Reports
|April 3, 2014
PubMed
Summary
This summary is machine-generated.

Statistical shape and appearance models aid in medical image analysis for osteoporosis. These models are crucial for fracture detection and risk estimation, improving patient outcomes.

More Related Videos

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

3.6K
Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
05:55

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head

Published on: September 27, 2024

1.1K

Related Experiment Videos

Last Updated: May 1, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

7.4K
Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

3.6K
Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
05:55

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head

Published on: September 27, 2024

1.1K

Area of Science:

  • Medical Image Analysis
  • Biomedical Engineering
  • Radiology

Background:

  • Statistical models (SMs) for shape (SSM) and appearance (SAM) have gained prominence in medical imaging since the 1990s.
  • Primarily used for segmentation, SMs also support 3D reconstruction and classification tasks.
  • Osteoporosis management requires accurate fracture detection and risk assessment.

Purpose of the Study:

  • To review the applications of SSMs and SAMs in the field of osteoporosis.
  • To discuss the benefits and drawbacks of using these statistical models for osteoporosis-related tasks.

Main Methods:

  • Literature review of statistical shape models (SSMs) and statistical appearance models (SAMs).
  • Focus on applications within the osteoporosis domain.
  • Analysis of model performance for segmentation, 3D reconstruction, and classification relevant to osteoporosis.

Main Results:

  • SSMs and SAMs offer versatile tools for medical image analysis in osteoporosis.
  • These models are applicable to key tasks such as fracture detection and risk estimation.
  • The review highlights specific use cases and their impact on osteoporosis assessment.

Conclusions:

  • Statistical shape and appearance models are valuable for osteoporosis research and clinical applications.
  • Understanding their advantages and disadvantages is crucial for effective implementation.
  • Further research may enhance the utility of these models in combating osteoporosis.