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Updated: May 1, 2026

Strategies for Study of Neuroprotection from Cold-preconditioning
Published on: September 2, 2010
Carboxypeptidase E (NF-α1): a new trophic factor in neuroprotection
Yong Cheng1, Niamh X Cawley, Y Peng Loh
1Section on Cellular Neurobiology, Program on Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
Abstract:
Carboxypeptidase E (CPE) is a prohormone-processing enzyme and sorting receptor that functions intracellularly. However, recent studies have demonstrated that CPE acts as a trophic factor extracellularly to up-regulate the expression of a pro-survival gene. This mini-review summarizes the roles of CPE in neuroprotection and the implications for neurodegenerative diseases.
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