Total hip replacement in HIV-positive patients.
S M Graham1, N Lubega, N Mkandawire
1The Countess Of Chester Hospital, Health Park, Chester, Cheshire, UK.
The Bone & Joint Journal
|April 3, 2014
Summary
Total hip replacement (THR) is safe for HIV-positive patients without hemophilia or IV drug use history. This study found no early or late infections and good functional outcomes after THR in this patient group.
Area of Science:
- Orthopedic Surgery
- Infectious Diseases
- HIV Medicine
Background:
- Total hip replacement (THR) is a common procedure for hip joint issues.
- Concerns exist regarding surgical outcomes in HIV-positive patients due to potential immune system compromises.
Purpose of the Study:
- To evaluate the safety and functional outcomes of THR in HIV-positive patients without hemophilia or a history of intravenous drug use.
- To assess the incidence of early and late infections following THR in this specific patient cohort.
Main Methods:
- A retrospective study of 29 HIV-positive patients (39 THRs) with no history of hemophilia or intravenous drug use.
- Follow-up averaged 3 years and 6 months, assessing complications, functional outcomes (Harris Hip Score), and need for revision surgery.
Main Results:
- No early (<6 weeks) or late (>6 weeks) infections were reported post-THR.
- Significant improvement in mean Harris Hip Score from 27 pre-operatively to 86 post-operatively (p < 0.05).
- No revision procedures were required, and no aseptic loosening symptoms were observed.
Conclusions:
- Total hip replacement (THR) appears to be a safe procedure for HIV-positive patients without hemophilia or a history of intravenous drug use.
- Good short-term functional outcomes and no increased risk of infection were observed in this patient group.
Related Concept Videos
01:10Retrovirus Life Cycles
43.0K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
43.0K
01:26Sexually Transmitted Infections
2.0K
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
2.0K
01:29Pulmonary Tuberculosis I
1.7K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.7K