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Targeting extracellular ROS signaling of tumor cells

Georg Bauer1

  • 1Institute of Virology, Department of Medical Microbiology and Hygiene, University of Freiburg, Hermann-Herder Strasse 11, D-79104 Freiburg, Germany. georg.bauer@uniklinik-freiburg.de.

Anticancer Research
|April 3, 2014
PubMed

Insights

Tumor cells use NADPH oxidase (NOX1) and protective enzymes to survive. Inhibiting membrane-associated superoxide dismutase (SOD) triggers apoptosis by disrupting catalase and reducing proliferation signals.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Background:

  • Membrane-associated NADPH oxidase (NOX1) is expressed by malignant cells, producing superoxide anions that stimulate proliferation and signaling pathways.
  • Tumor cells utilize membrane-associated catalase and superoxide dismutase (SOD) for protection against reactive oxygen species (ROS)-induced apoptosis.

Purpose of the Study:

  • To investigate the functional interplay between NOX1, catalase, and SOD on the tumor cell surface.
  • To explore novel therapeutic strategies targeting extracellular ROS interactions in cancer.

Main Methods:

  • Analysis of the biochemical network on the surface of tumor cells.
  • Investigating the effects of specific inhibition of membrane-associated SOD.

Main Results:

  • Specific inhibition of membrane-associated SOD leads to superoxide anion-dependent catalase inhibition.
  • This inhibition triggers apoptosis via the NO/peroxynitrite pathway and reduces H2O2 levels, decreasing proliferation signals.

Conclusions:

  • The extracellular ROS interaction network on tumor cells presents a viable target for novel cancer therapies.
  • Targeting membrane-associated SOD offers a specific strategy to induce apoptosis and inhibit tumor growth.
Keywords:
NOX1ROSapoptosiscatalasereviewsuperoxide anionsuperoxide dismutase

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