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Inhibited interferon production after space flight.

G Sonnenfeld1, C L Gould, J Williams

  • 1Department of Microbiology and Immunology, University of Louisville School of Medicine and Dentistry, Kentucky.

Acta Microbiologica Hungarica
|January 1, 1988
PubMed
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Space flight and simulated microgravity impair rodent interferon production, affecting viral resistance. Immune function recovers after returning to normal conditions, suggesting transient immune alterations.

Area of Science:

  • Immunology
  • Space Biology
  • Virology

Background:

  • Space flight is known to impact physiological systems.
  • Interferon (IFN) production is crucial for antiviral defense.
  • Rodent models are used to study space flight effects on immunity.

Purpose of the Study:

  • To investigate the effects of space flight and simulated microgravity on interferon production in rodents.
  • To assess the impact of altered interferon levels on viral resistance.
  • To determine if immune function recovers after space flight exposure.

Main Methods:

  • Utilized an antiorthostatic suspension model to simulate microgravity effects.
  • Measured interferon-alpha/beta production in suspended mice.
  • Assessed resistance to encephalomyocarditis virus infection in suspended mice.
Keywords:
NASA Center ARCNASA Discipline Regulatory PhysiologyNon-NASA Center

Related Experiment Videos

  • Analyzed interferon-gamma and interleukin-3 production in rats flown on Space Shuttle mission SL-3.

    • Main Results:

    • Antiorthostatic suspension inhibited interferon-alpha/beta production in mice.
    • This inhibition was transient, with normal production upon recovery.
    • Suspended mice showed reduced resistance to viral infection, correlating with lower interferon levels.
    • Rats from space flight exhibited severely inhibited interferon-gamma production but normal interleukin-3 production.

    Conclusions:

    • Space flight and simulated microgravity can transiently impair interferon production in rodents.
    • Reduced interferon levels are associated with decreased resistance to viral infections.
    • These findings suggest significant alterations in immune responses, particularly antiviral defenses, following space missions.