Related Experiment Video
Updated: May 1, 2026
10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
23.9K
Gluten sensitivity presenting as a neuropsychiatric disorder
Stephen J Genuis1, Rebecca A Lobo2
1Faculty of Medicine, University of Alberta, Edmonton, AB, Canada T6K 4C1.
Gastroenterology Research and Practice
|April 3, 2014
Summary
Gluten sensitivity, including nonceliac gluten sensitivity (NCGS), is increasingly recognized. Eliminating gluten can significantly improve unexplained symptoms, even neuropsychiatric ones, highlighting its importance in clinical practice.
Area of Science:
- Gastroenterology
- Neurology
- Immunology
Background:
- Gluten sensitivity is a growing health concern, extending beyond celiac disease (CD).
- Nonceliac gluten sensitivity (NCGS) presents with symptoms similar to CD but without the classical diagnostic markers.
- NCGS symptoms are triggered by gluten and improve with a gluten-free diet.
Purpose of the Study:
- To review the current understanding of gluten sensitivity.
- To explore the link between gluten sensitivity and neuropsychiatric conditions.
- To present a case study demonstrating the impact of gluten elimination on severe symptoms.
Main Methods:
- Literature review of gluten sensitivity and associated conditions.
- Clinical case presentation of a patient with NCGS and neuropsychiatric symptoms.
- Discussion of potential pathophysiologic mechanisms.
Main Results:
- NCGS is frequently reported, characterized by gluten-induced symptoms that resolve with dietary changes.
- Emerging evidence links gluten sensitivity to neuropsychiatric disorders like autism, schizophrenia, and ataxia.
- A case study showed significant improvement in auditory and visual hallucinations after gluten elimination.
Conclusions:
- Physicians should consider gluten sensitivity in patients with unexplained symptoms.
- Gluten elimination can lead to life-changing improvements for individuals with NCGS.
- Further research into the mechanisms of gluten sensitivity's multisystem effects is warranted.
Related Concept Videos
01:30Other Disorders of Digestive System
1.7K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.7K
01:19Multiple Sclerosis l: Introduction
20
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
20
01:30Drug Toxicity: Allergic Reactions
209
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
209
01:30Bulimia Nervosa
1.1K
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
1.1K
01:28Disorders of the Nervous Tissue
3.0K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
3.0K
01:28Graves' Disease I: Introduction
23
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence...
23