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Updated: Aug 13, 2026

Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
Published on: December 26, 2016
Molecular biology in psychiatric research: Alzheimer's disease as a paradigm
1Department of Psychiatry and Neuroscience Program, Harvard Medical School.
Abstract:
As illustration of the integration of molecular biological studies into psychiatric research, use of molecular techniques in the study of Alzheimer's disease is described, and the resultant observation of otherwise undetectable pathological changes is noted. Using postmortem Alzheimer brain messenger RNA, recombinant DNA studies led to the ability to clone and characterize the expressed genetic transcript for amyloid. Application of this methodology is discussed in terms of establishing cellular and animal models for a neuropsychiatric disease.
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