Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Graves' disease in childhood].

S Maldonado Regalado1, R Barrio Castellanos, M Alonso Blanco

  • 1Servicio de Pediatría, Hospital Ramón y Cajal, Madrid.

Anales Espanoles De Pediatria
|December 1, 1988
PubMed
Summary

This study on pediatric Graves' disease found that high T3/T4 ratios and specific symptoms indicated poor prognosis. Antithyroid drugs achieved remission in most young patients, but relapses occurred, highlighting the need for careful monitoring.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[T3-predominant Graves' disease in paediatric patients].

Anales de pediatria (Barcelona, Spain : 2003)·2015
Same author

[Nine-year longitudinal study of cardiovascular risk factors in Spanish children and adolescents with type 1 diabetes].

Anales de pediatria (Barcelona, Spain : 2003)·2014
Same author

[Type 2 diabetes mellitus in adolescents in a pediatric diabetes unit].

Anales de pediatria (Barcelona, Spain : 2003)·2014
Same author

[Latent autoimmune diabetes in the young].

Anales de pediatria (Barcelona, Spain : 2003)·2013
Same author

[Efficacy of treatment with I(131) in paediatric Graves disease].

Anales de pediatria (Barcelona, Spain : 2003)·2013
Same author

[Treatment of the child and adolescent with type 1 diabetes: special paediatric diabetes units].

Anales de pediatria (Barcelona, Spain : 2003)·2012

Area of Science:

  • Pediatric endocrinology
  • Autoimmune thyroid disorders
  • Graves' disease management

Context:

  • Graves' disease is the most common cause of hyperthyroidism in children and adolescents.
  • Clinical presentation and therapeutic outcomes in pediatric Graves' disease can vary significantly.
  • Understanding prognostic factors is crucial for effective long-term management.

Purpose:

  • To report clinical and therapeutic outcomes in a cohort of pediatric Graves' disease patients.
  • To identify peculiar clinical features and laboratory findings associated with the disease.
  • To evaluate the efficacy of antithyroid drug treatment and identify markers for remission.

Summary:

  • Seven hyperthyroid Graves' disease patients (age 3.5-15.5 years) were studied, noting unusual cases like pretibial myxedema and absence of goiter.

Related Experiment Videos

  • Elevated T4, T3 levels, and a T3/T4 ratio ≥20 were observed in most patients, suggesting a poor prognosis.
  • Two years of high-dose antithyroid drug treatment led to remission in five patients (71%), with two relapses (40% of remissions).

    • Impact:

    • Identifies specific laboratory markers (T3/T4 ratio) and clinical signs (pretibial myxedema) as potential indicators of disease severity in children.
    • Demonstrates the effectiveness of antithyroid drugs as an initial treatment for pediatric Graves' disease, with a significant remission rate.
    • Recommends individualized treatment duration and the use of specific remission markers (TSH receptor antibodies, T3 suppression test, okt4/okt8 ratio) for monitoring treatment success.