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Pituitary dependence of bone marrow function.

E Nagy1, I Berczi

  • 1Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

British Journal of Haematology
|April 1, 1989
PubMed
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Pituitary grafts or prolactin and growth hormone treatments restored bone marrow function in hypophysectomized rats. These hormones regulate bone marrow activity, impacting blood cell synthesis and DNA/RNA production.

Area of Science:

  • Endocrinology
  • Hematology
  • Molecular Biology

Background:

  • Hypophysectomy in rats leads to anemia, leucopenia, and thrombocytopenia.
  • Impaired DNA and RNA synthesis in bone marrow is observed post-hypophysectomy.

Purpose of the Study:

  • To investigate the role of the pituitary gland in regulating bone marrow function.
  • To identify specific pituitary hormones responsible for maintaining bone marrow health.

Main Methods:

  • Hypophysectomized rats were used as a model.
  • Treatment groups received syngeneic pituitary grafts, ovine/bovine prolactin, growth hormone, ACTH, FSH, LH, or TSH.
  • Hematological parameters and DNA/RNA synthesis were assessed.

Main Results:

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  • Pituitary grafts restored normal blood cell counts and DNA/RNA synthesis.
  • Prolactin and growth hormone treatments effectively reversed the bone marrow deficiencies.
  • ACTH, FSH, LH, and TSH treatments showed no beneficial effect on bone marrow function.

Conclusions:

  • The pituitary gland plays a crucial role in regulating bone marrow function.
  • Prolactin and growth hormone are key pituitary hormones involved in maintaining hematopoiesis and bone marrow cellularity.