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18F-FDG PET or PET/CT for detecting extensive disease in small-cell lung cancer: a systematic review and
Yu-Yu Lu1, Jin-Hua Chen, Ji-An Liang
1aDepartment of Nuclear Medicine, Taichung Veterans General Hospital bDepartment of Radiation Oncology cDepartment of Nuclear Medicine and PET Center, China Medical University Hospital dSchool of Medicine, China Medical University, Taichung eSchool of Public Health, Taipei Medical University, Taipei, Taiwan fSchool of Biological Sciences, University of California, Irvine, California, USA.
Abstract:
The purpose of this study was to conduct a systematic review and meta-analysis of the published literature to evaluate the diagnostic accuracy of fluorine-18 2-fluoro-2-deoxy-D-glucose (F-FDG) PET or PET/computed tomography (CT) in the pretherapeutic staging of patients with small-cell lung cancer (SCLC). The authors conducted a systematic MEDLINE search of published articles. Two reviewers independently assessed the methodological quality of each study. We estimated the pooled sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR-), and summary receiver operating characteristic curves in the detection of extensive disease (ED) in patients with SCLC. Twelve studies with a total of 369 patients met the inclusion criteria. The pooled estimates of sensitivity, specificity, LR+, and LR- of F-FDG PET or PET/CT for the detection of ED in SCLC were 97.5% [95% confidence interval (CI), 94.2-99.2%], 98.2% (95% CI, 94.9-99.6%), 19.86 (95% CI, 9.79-40.30), and 0.06 (95% CI, 0.03-0.10), respectively. Whole-body F-FDG PET or PET/CT is a valuable imaging tool for the pretherapeutic assessment of ED in patients with SCLC.
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