Spinal input to the parabrachial nucleus in the cat

The projections from the spinal cord to the parabrachial nucleus in the cat were investigated using both the degeneration method and the anterograde transport of wheat germ agglutinin-horseradish peroxidase conjugate. Both methods produced similar results. Spinal input to the parabrachial nucleus was bilateral, with a slight contralateral predominance. The termination area was localized predominantly in the dorsal part of the lateral parabrachial nucleus, with additional limited terminations in the Kölliker-Fuse subnucleus. Projections from different rostrocaudal levels of the spinal cord overlapped completely, suggesting that spinal input to the parabrachial nucleus is not topographically organized. Taking these results together with those of others indicating that spinal input to the parabrachial nucleus arises primarily from nociceptive-specific neurons in lamina I of the dorsal horn, it is concluded that the spinal projections to the parabrachial nucleus are likely to be involved in various generalized aspects of nociception.