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Attention-Deficit/Hyperactivity Disorder01:30

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Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
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Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
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Post-Error Slowing in Patients With ADHD: A Meta-Analysis.

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Individuals with Attention-Deficit/Hyperactivity Disorder (ADHD) exhibit reduced post-error slowing (PES) compared to controls. This diminished adaptive response may serve as a behavioral marker for ADHD.

Keywords:
ADD/ADHDbehavioral regulationcontinuous performance taskseffect sizeinhibition

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Area of Science:

  • Cognitive Neuroscience
  • Neurodevelopmental Disorders

Background:

  • Post-error slowing (PES) is a crucial cognitive mechanism for error correction and adaptive behavior.
  • Previous research has not meta-analytically assessed differences in PES between individuals with Attention-Deficit/Hyperactivity Disorder (ADHD) and healthy controls.

Purpose of the Study:

  • To conduct a meta-analysis evaluating differences in PES between ADHD patients and healthy controls.
  • To determine if PES can serve as a behavioral indicator for ADHD.

Main Methods:

  • A systematic search identified 15 relevant studies, yielding 26 comparisons.
  • Random-effects meta-analysis was employed to calculate the effect size (ES) for PES differences.
  • Data included 1,053 individuals with ADHD and 614 healthy controls.

Main Results:

  • A medium effect size (Cohen's d = 0.42) indicated diminished PES in the ADHD group compared to controls.
  • Inter-stimulus interval (ISI) modulated group differences: healthy participants showed longer PES with longer ISIs, while ADHD participants did not slow down or even sped up.

Conclusions:

  • The significant reduction in PES in individuals with ADHD suggests a potential impairment in error-monitoring and adaptive control.
  • Diminished PES may represent a valuable behavioral biomarker for distinguishing ADHD from typical development.