Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Directional motion of a self-steering active intruder in a dense crowd of cognitive active agents.

Scientific reports·2026
Same author

Rosette margination in blood flow during malaria pathogenesis.

Biophysical journal·2025
Same author

Reversible formation of von-Willebrand-factor-platelet aggregates in microvascular blood flow.

PNAS nexus·2025
Same author

Tunable colloidal swarmalators with hydrodynamic coupling.

Nature communications·2025
Same author

Wrapping of Nano- and Microgels by Lipid-Bilayer Membranes.

ACS macro letters·2025
Same author

Run-and-tumble dynamics of <i>Escherichia coli</i> is governed by its mechanical properties.

Journal of the Royal Society, Interface·2025

Related Experiment Video

Updated: May 1, 2026

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

15.6K

White blood cell margination in microcirculation.

Dmitry A Fedosov1, Gerhard Gompper

  • 1Theoretical Soft Matter and Biophysics, Institute of Complex Systems, Institute for Advanced Simulation, Forschungszentrum Jülich, 52425 Jülich, Germany. d.fedosov@fz-juelich.de.

Soft Matter
|April 4, 2014
PubMed
Summary
This summary is machine-generated.

White blood cell margination, crucial for immune function, is most efficient at intermediate hematocrit (0.2-0.4) and low flow rates. Red blood cell aggregation also enhances this white cell migration process.

More Related Videos

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

3.0K
Controlled Microfluidic Environment for Dynamic Investigation of Red Blood Cell Aggregation
10:27

Controlled Microfluidic Environment for Dynamic Investigation of Red Blood Cell Aggregation

Published on: June 4, 2015

11.5K

Related Experiment Videos

Last Updated: May 1, 2026

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

15.6K
A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

3.0K
Controlled Microfluidic Environment for Dynamic Investigation of Red Blood Cell Aggregation
10:27

Controlled Microfluidic Environment for Dynamic Investigation of Red Blood Cell Aggregation

Published on: June 4, 2015

11.5K

Area of Science:

  • Biophysics
  • Computational Biology
  • Hematology

Background:

  • White blood cell (WBC) adhesion to vascular endothelium is essential for immune response.
  • This adhesion requires WBCs to be near vessel walls, facilitated by margination.
  • Margination is influenced by hematocrit, flow rate, red blood cell (RBC) aggregation, and cell deformability.

Purpose of the Study:

  • To quantitatively investigate white blood cell margination using advanced simulations.
  • To determine optimal conditions for WBC margination in blood flow.
  • To explore the impact of RBC aggregation on WBC margination.

Main Methods:

  • Mesoscopic hydrodynamic simulations of a 3D blood flow model.
  • Analysis of WBC margination across a range of hematocrit values and flow conditions.
  • Incorporation of RBC aggregation effects within the simulation.

Main Results:

  • Efficient WBC margination occurs at intermediate hematocrit (Ht ≈ 0.2-0.4).
  • Low flow rates, typical of venules, promote effective margination.
  • RBC aggregation significantly enhances WBC margination.

Conclusions:

  • The study provides a quantitative understanding of WBC margination dynamics.
  • Optimal margination conditions are identified for microcirculation.
  • Findings are relevant for understanding the margination of other particles, including circulating tumor cells.