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Published on: January 7, 2018
[Hypertension in early school aged children born prematurely with extremely low birth weight]
Insights
Extremely low birth weight (ELBW) infants are at higher risk for developing arterial hypertension (HT) later in childhood. This condition is more prevalent in prematurely born girls, necessitating regular blood pressure monitoring.
Area of Science:
- Pediatrics
- Cardiology
- Neonatology
Context:
- Extremely low birth weight (ELBW) infants face significant health risks.
- Arterial hypertension (HT) is a potential long-term complication in this vulnerable population.
Purpose:
- To investigate the predisposition of ELBW infants to arterial hypertension (HT).
- To assess HT development in a 7-year follow-up of ELBW children.
Summary:
- A cohort of 57 ELBW infants (mean gestational age 27.4 weeks) was compared to 36 full-term controls.
- Ambulatory Blood Pressure Measurement (ABPM) revealed significantly higher rates of HT (based on mean arterial pressure and BP load) in ELBW children.
- Preterm infants exhibited higher systolic and diastolic BP loads, heart rate, and were shorter than controls. Girls born with ELBW had higher BP and MAP than boys.
Impact:
- ELBW infants are predisposed to developing arterial hypertension later in life.
- Prematurely born girls show a higher incidence of HT.
- Early diagnosis and management of HT in ELBW children can mitigate risks of multi-organ complications.
Background:
Infants born with extremely low birth weight < or =1000 g (ELBW) are endangered by many complications.
Aim:
To assess whether infants born prematurely with ELBW are pre. disposed to arterial hypertension (HT) in a 7-year follow up examination.
Material And Methods:
A group of 57 children (38 girls, 19 boys) at the age of 6.6+/-0.4 years was analyzed. Mean gestational age was 27.4+/-2 Hbd. All infants were born with ELBW (the mean weight was 861+/-127 g). The con. trol group consisted of 36 children (19 girls and 15 boys; the mean age was 7+/-0.9 years) born on time, with the mean birth weight 3559 g. The Ambu. latory Blood Pressure Measurement (ABPM) was performed in both groups. Mean arterial pressure (MAP), the night blood pressure (BP) decrease, BP. load, heart rate (HR) and presence of HT were analyzed.
Results:
Children born prematurely were significantly shorter than children from the control group (116 vs 125 cm; p<0.0001). HT diagnosis based both on MAP (15% vs 0%; p<0.02) and on BP loads (51% vs 22%; p<0.006), was significantly more common in the group of preterm infants. Moreo. ver, systolic BP-load (28% vs 17%; p<0.01), diastolic BP-load (27% vs 18%; p<0.01), daytime HR (99 vs 94/ min; p=0.01), nighttime HR (86 vs 791 min; p<0.001) and daily HR (93 vs 87/ min; p<0.001) were also significantly higher in the preterm group. Difference in night BP drops in both groups did not reach statistical significance. In the group of former preterms there was no correlation between birth weight or intrauterine growth and BP value. BP values: systolic (105 vs 100 mm Hg; p<0.02), diastolic (66 vs 63 mm Hg; p<0.01) and MAP (80 vs 76 mm Hg; p<0.01) were significantly higher in girls than in boys born prematurely with ELBW.
Conclusion:
Infants born with ELBW are latterly predisposed to HT. Hypertension is more frequent in prematurely born girls. It is important to control BP in this group of children because early diagnose helps to decrease the risk of multiple organ complications caused by HT.
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