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Updated: May 1, 2026
Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
Published on: November 17, 2015
Physico-chemical characterisation, cytotoxic activity, and biocompatibility studies of tamoxifen-loaded solid lipid
Sushant Lakkadwala1, Sanko Nguyen, Joseph Lawrence
1Division of Industrial Pharmacy, Department of Pharmacy Practice, College of Pharmacy and Pharmaceutical Sciences, University of Toledo , Toledo, Ohio , USA .
Context:
Solid lipid nanoparticles (SLNs) can efficiently and efficaciously incorporate anti-cancer agents.
Objective:
To prepare and characterise tamoxifen (TAM)-loaded SLNs.
Materials And Methods:
Glyceryl monostearate, Tween-80, and trehalose were used in SLNs. SLNs were tested via dynamic light scattering (DLS), transmission electron microscopy (TEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR).
Results:
Characterisation studies revealed SLNs of about 540 nm with a negative surface charge and confirmed the entrapment of TAM in the SLNs. The entrapment efficiency was estimated to be 60%.
Discussion:
The in vitro drug release profile demonstrated a gradual increase followed by a release plateau for several days. A drug concentration-dependent increase in cytotoxic activity was observed when the SLNs were evaluated in cell cultures.
Conclusion:
Biocompatible and stable lyophilised SLNs were successfully prepared and found to possess properties that may be utilised in an anti-cancer drug delivery system.
