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Related Concept Videos

Ion Channels01:19

Ion Channels

68.1K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
68.1K
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

11.2K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
11.2K
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

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7.6K
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

4.6K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.6K
Non-gated Ion Channels01:24

Non-gated Ion Channels

7.3K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
7.3K
Non-gated Ion Channels01:24

Non-gated Ion Channels

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Related Experiment Video

Updated: May 1, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

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Ion channels and migraine.

Jin Yan1, Gregory Dussor

  • 1Department of Pharmacology, University of Washington, Seattle, WA, USA.

Headache
|April 5, 2014
PubMed
Summary
This summary is machine-generated.

Migraine, a common neurological disorder, involves poorly understood pain mechanisms. This review explores the trigeminovascular pathway

Keywords:
TWIK-related spinal cord potassium channelacid sensing ion channeldural afferenttransient receptor potential cation channel A1transient receptor potential cation channel V1transient receptor potential cation channel V4

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Area of Science:

  • Neurology
  • Neuroscience
  • Pain Research

Background:

  • Migraine is a prevalent neurological disorder with complex underlying mechanisms.
  • Current understanding of migraine pathophysiology, particularly molecular and mechanistic aspects, remains limited.
  • Head-specific pain in migraine points to the involvement of peripheral nociceptors in the head.

Purpose of the Study:

  • To review the current understanding of biological mechanisms in migraine.
  • To focus on the activation and sensitization of the trigeminovascular pain pathway.
  • To highlight recent advances in ion channel activation and modulation relevant to migraine.

Main Methods:

  • Literature review of current research on migraine pathophysiology.
  • Analysis of studies focusing on the trigeminovascular system.
  • Examination of recent findings on ion channel function in pain pathways.

Main Results:

  • The trigeminovascular pathway plays a crucial role in migraine headache.
  • Activation and sensitization of this pathway are key to episodic migraine.
  • Ion channels are critical modulators of trigeminovascular activation and sensitization.

Conclusions:

  • Understanding trigeminovascular activation and ion channel modulation is vital for developing effective migraine treatments.
  • Further research into these mechanisms could unlock new therapeutic strategies.
  • Targeting ion channels offers a promising avenue for future migraine therapies.