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    Summary

    Seaweeds, rich in bioactive compounds, show potential for chronic disease management. This review highlights human study evidence and identifies knowledge gaps for future research on seaweed health benefits.

    Area of Science:

    • Marine biotechnology
    • Nutritional science
    • Human health and disease

    Background:

    • Seaweeds possess unique bioactive compounds like polysaccharides and polyphenols, absent in terrestrial foods.
    • These compounds offer potential health benefits, including antiviral, anticancer, and metabolic modulation.
    • Existing research predominantly uses cell and animal models, with limited human data.

    Purpose of the Study:

    • To critically evaluate existing human studies on seaweed's health effects.
    • To identify gaps in current knowledge regarding seaweed consumption in humans.
    • To guide future research for effective human health applications of seaweed.

    Main Methods:

    • Systematic review and critical evaluation of human clinical trials.

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  • Analysis of studies investigating the impact of seaweed and its components on human health markers.
  • Identification and synthesis of evidence from human intervention studies.

    • Main Results:

    • Evidence suggests beneficial effects of seaweed on human health markers.
    • Human studies demonstrate potential roles in modulating chronic disease risk factors.
    • Significant gaps exist in the quality and quantity of human clinical data.

    Conclusions:

    • Seaweed consumption shows promise for human health and chronic disease modulation.
    • Further rigorous human studies are needed to confirm and expand upon current findings.
    • Addressing knowledge gaps will facilitate the development of seaweed-based health interventions.