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Influence of covariance between random effects in design for nonlinear mixed-effect models with an illustration in

Cyrielle Dumont1, Marylore Chenel, France Mentré

  • 1a Université Paris Diderot, Sorbonne Paris Cité , UMR 738, INSERM, Paris , France.

Journal of Biopharmaceutical Statistics
|April 5, 2014
PubMed

Keywords:
D-optimalityFisher information matrixNonlinear mixed effect modelsOptimal designPFIMPediatric studiesPopulation pharmacokinetics

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