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Does fatigue occur in MS patients without disability?

Helcio Alvarenga-Filho1, Regina Maria Papais-Alvarenga, Sonia Regina Carvalho

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The International Journal of Neuroscience
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Fatigue is common in multiple sclerosis (MS) patients even without motor issues, linked to the disease, inactivity, and mood disorders. The 6-minute walk test (6MWT) doesn

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Clinical Psychology

Background:

  • Multiple sclerosis (MS) commonly causes motor dysfunction and fatigue.
  • Fatigue assessment in MS patients often relies on walk tests and scales, even in those with varying disability levels.

Purpose of the Study:

  • To evaluate both objective and subjective fatigue in multiple sclerosis (MS) patients who exhibit no motor disability.
  • To identify factors associated with fatigue in early-stage MS.

Main Methods:

  • Selected MS patients (relapsing-remitting, EDSS 0-1.5) and age/gender/BMI/activity-matched controls.
  • Excluded participants with fatigue from other medical conditions.
  • Administered the 6-minute walk test (6MWT), MS Functional Composite (MSFC), Modified Fatigue Impact Scale (MFIS), and Beck Depression Inventory.

Main Results:

  • No significant differences in MSFC or 6MWT between MS patients and controls.
  • 35% of MS patients reported fatigue (MFIS), with significant differences in physical, cognitive, and psychosocial domains compared to controls.
  • Fatigue in MS was associated with the disease, low physical activity, and mood disorders.

Conclusions:

  • Fatigue is prevalent in MS patients even without motor impairment.
  • Sedentary lifestyle and mood disorders are linked to fatigue in MS.
  • The 6MWT is not a reliable indicator of motor fatigue in MS patients without neurological disability.