Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dosage Regimen Designs: Nomograms and Tabulations01:23

Dosage Regimen Designs: Nomograms and Tabulations

353
Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...
353
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

600
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
600
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

342
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
342
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

3.1K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
3.1K
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

168
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
168

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gonadotropin Releasing Hormone agonist (GnRHa) during chemotherapy and post-cancer childbirths - a Nationwide population-based cohort study of 24,922 women diagnosed with cancer in Sweden.

EClinicalMedicine·2024
Same author

Validation of diagnoses of liver disorders in users of systemic azole antifungal medication in Sweden.

BMC gastroenterology·2024
Same author

Prenatal opioid exposure and risk of asthma in childhood: a population-based study from Denmark, Norway, and Sweden.

Frontiers in pharmacology·2023
Same author

Prenatal exposure to pregabalin, birth outcomes and neurodevelopment - a population-based cohort study in four Nordic countries.

Drug safety·2023
Same author

Atomoxetine in Early Pregnancy and the Prevalence of Major Congenital Malformations: A Multinational Study.

The Journal of clinical psychiatry·2023
Same author

In-utero antibiotic exposure and subsequent infections in infancy: a register-based cohort study with sibling analysis.

American journal of obstetrics & gynecology MFM·2023

Related Experiment Video

Updated: May 1, 2026

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm
05:44

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm

Published on: March 1, 2019

7.7K

Nordic databases to evaluate medications in pregnancy.

Helle Kieler

    Therapie
    |April 5, 2014
    PubMed
    Summary

    Nordic health registers offer robust data for studying medications during pregnancy. These extensive national databases allow for comprehensive analysis of maternal drug use and its health impacts beyond congenital abnormalities.

    Area of Science:

    • Pharmacovigilance
    • Reproductive Health
    • Public Health Research

    Background:

    • Nordic countries (Denmark, Finland, Iceland, Norway, Sweden) possess comprehensive national health registers.
    • These registers contain long-term data on births, cancer diagnoses, hospitalizations, mortality, and dispensed medications.
    • A population of 25 million is covered by these integrated health data systems.

    Purpose of the Study:

    • To outline the utility of Nordic health registers for assessing medication safety in pregnancy.
    • To highlight the potential for studying a wide range of health outcomes associated with maternal drug exposure.
    • To emphasize the value of these registers for pharmacoepidemiological research in pregnancy.

    Main Methods:

    • Review of the capabilities and data content of Nordic national health registers.

    More Related Videos

    Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
    19:15

    Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

    Published on: August 25, 2014

    90.5K
    Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
    09:04

    Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

    Published on: September 10, 2018

    8.4K

    Related Experiment Videos

    Last Updated: May 1, 2026

    Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm
    05:44

    Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm

    Published on: March 1, 2019

    7.7K
    Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
    19:15

    Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

    Published on: August 25, 2014

    90.5K
    Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
    09:04

    Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

    Published on: September 10, 2018

    8.4K
  • Description of how these registers can be utilized for cohort studies and drug safety surveillance.
  • Identification of specific data points relevant to pregnancy and medication use.

    • Main Results:

    • Nordic health registers provide a powerful resource for evaluating drugs used during pregnancy.
    • The data allows for the assessment of various maternal and infant health outcomes.
    • Previous research has primarily focused on congenital abnormalities, but other risks can now be investigated.

    Conclusions:

    • The Nordic health registers are a valuable tool for comprehensive drug safety assessment in pregnant populations.
    • These registers facilitate research into the broader health consequences of maternal medication.
    • Future research can leverage these resources to enhance understanding of medication effects during pregnancy.