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Healing after regenerative procedures with and without pulpal infection
Ashraf F Fouad1, Prashant Verma1
1Department of Endodontics, Prosthodontics and Operative Dentistry, School of Dentistry, University of Maryland, Baltimore, Maryland.
Journal of Endodontics
|April 5, 2014
Summary
Regenerative endodontics shows promise for immature teeth with pulp necrosis. Disinfection strategies must balance infection control with preserving stem cells for successful dental pulp regeneration.
Area of Science:
- Dentistry
- Regenerative Medicine
- Endodontics
Background:
- Regenerative endodontic procedures (REPs) are gaining interest for immature teeth with pulp necrosis.
- Preclinical studies demonstrate dental pulp regeneration potential.
- Clinical case reports show infection control and root development.
Purpose of the Study:
- To review factors influencing clinical decisions in regenerative endodontics for immature teeth.
- To discuss the microbiology of endodontic infections.
- To evaluate antimicrobial strategies and procedural outcomes.
Main Methods:
- Literature review of preclinical studies, case reports, and case series.
- Analysis of factors affecting REPs in immature teeth.
- Examination of antimicrobial strategies and their impact on stem cells and dentin.
Main Results:
- Preoperative infection is a key prognostic factor for REPs.
- Antimicrobial strategies for REPs differ from mature teeth, requiring higher disinfection levels.
- Balancing disinfection with preserving stem cell viability and dentin bioactivity is crucial.
Conclusions:
- Successful REPs depend on appropriate antimicrobial protocols that preserve the regenerative potential of the root canal system.
- Further research is needed to optimize disinfection and regenerative techniques for immature teeth.
- Clinical decision-making should consider infection control, stem cell viability, and dentin bioactivity.
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